This network has a primary hub of UBC, which is related to an increase in expression of FKBP15 and ATPase, H+ transporting, lysosomal 70 kDa, and V1 subunit A (ATP6V1A), and reductions in the expression of TSEN54 tRNA splicing endonuclease and megalencephalic leukoencephalopathy with subcortical cysts 1. The gene discussed is ATP6V1A; the disease is leukoencephalopathy, megalencephalic.