ABL1 and chronic myelogenous leukemia, BCR-ABL1 positive: The best documented case of targeted therapy in cancer molecular biology is that of the Tyrosine Kinase inhibitors (TKIs), which target the kinase domain of the BCR-ABL protein, which is responsible for the pathogenesis of chronic myelogenous leukemia (CML) through the enhancement of the proliferation and viability of myeloid cell lineage (Evans et al., 1993).