Strikingly, despite specific infiltration of the brain by functional self-reactive CD8+ T cells and specific antigen processing and presentation by both neuronal cells and CD11b+ microglia, no clinical sign of autoimmune neuroinflammation or CNS damages was observed in Aβ33-41NP-immunized APPPS1 mice. The gene discussed is ITGAM; the disease is Autoimmunity.