Wen et al. [14] demonstrated that autologous Id-specific cytotoxic T cells of both CD8+ and CD4+ lineage generated from MM patients can lyse Id-pulsed autologous dendritic cells and autologous myeloma plasma cells, providing proof of concept, with the existence of cytotoxic CD4+ T cells increasingly recognised in recent decades [15]. This evidence concerns the gene CD4 and plasma cell myeloma.