Pre-clinically, using the murine MOPC-315 plasmacytoma model, Bogen et al. [38] demonstrated that vaccine-induced T-cell responses to an Id of the myeloma protein M315 were heavily influenced by the quaternary structure of the stimulating protein in a proliferation assay, with a 100-fold to 1000-fold higher molar concentration of Fab or whole IgA needed to induce equivalent responses to Fv, suggesting that whole Ig is poorly processed in vitro, and possible in vivo, which may explain the relatively low frequency of anti-Id responses observed. The gene discussed is FANCB; the disease is plasmacytoma.