As was shown by Rausch et al. [35], the single nucleotide variant (SNV) rate of children with Sonic-Hedgehog medulloblastoma (SHH-MB) is clearly higher (24 tumor-specific SNVs) in the case of inherited TP53 mutations compared to sporadic pediatric medulloblastoma samples (average 5.7 non-synonymous SNVs per sample; [32]). The gene discussed is TP53; the disease is neoplasm.