Moreover, recent quantitative studies of metabolic genes obtained from liver biopsies suggests that 18 F-FDG uptake in HCC is linked to expression of acetyl Coenzyme-A (CoA)-Synthetase-1 (ACSS1) an enzyme that generates acetyl-CoA from acetate and CoA, with the hydrolysis of ATP to AMP and diphosphate [49, 50]. Here, ACSS1 is linked to hepatocellular carcinoma.