Increased expression of periostin in tissues has also been associated with several inflammatory conditions that have been investigated in the fields of eosinophilia (e.g., otitis media, eosinophilic esophagitis), ophthalmology (e.g., proliferative diabetic retinopathy), hematology (e.g., bone marrow fibrosis),and fibrotic remodeling (e.g., immunoglobulin (Ig)G4-related sclerosing sialadenitis and scleroderma) [5]. This evidence concerns the gene POSTN and Increased total eosinophil count.