AGTR1 and Hypertension: Furthermore, increased frequency of a SNP at 1166 position (A/C transversion) in the 3′ UTR of AGTR1 has been associated with hypertension (Bonnardeaux et al., 1994), cardiac hypertrophy (Osterop et al., 1998), myocardial infarction (Tiret et al., 1994) and increased oxidative stress levels in human heart failure (Cameron et al., 2006).