Furthermore, AGTR1 signalling plays an important role in increasing VEGF expression by Cancer Associated Fibroblasts (CAFs) (Fujita et al., 2005), thus both ACE and AGTR1 inhibitors could be used to target VEGF expression and angiogenesis (Suganuma et al., 2005, Yoshiji et al., 2001). Here, AGTR1 is linked to cancer.