Knockdown of GPR116 in MDA-MB-231, a triple negative, hormone-insensitive and metastatic breast cancer cell line results in significant decrease in cell migration and invasion, suggesting that GPR116 promotes BCa cell migration and invasion via Gαq signalling and p63RhoGEF (a Gαq effector) mediated activation of the RhoA and Rac1 (Tang et al., 2013). The gene discussed is GNAQ; the disease is breast cancer.