Moreover, the activation of endothelin receptors, bradykinin receptors, the Angiotensin II type I receptors (AGTR1) (de Gasparo et al., 2000, Rhodes et al., 2009) and gastrin-releasing peptide receptors (GRPR) has been implicated in prostate cancer pathogenesis (Daaka, 2004). The gene discussed is GRPR; the disease is Familial prostate cancer.