CXCR4 and myocardial infarction: Moreover, Tano et al. showed that the number of circulating mononuclear cells (MNCs) as well as of CXCR4 positive MNCs were increased by acute IHD (an heart attack) in patients and identified miR-150 as a key regulator for mobilizing these cells from the BM by targeting CXCR4 [133].