EGFR and lung carcinoma: The anti-tumor effect of WJ was abolished in Y1045F-mutant EGFR A549-Luc orthotopic lung tumors and WJ induced-EGFR degradation in wild-type EGFR A549 tumors was not seen in Y1045F-mutant EGFR A549 tumors (Figure 6B and 6C), indicating the critical role of EGFR in lung cancer formation.