Of 9 patients (melanoma, n = 6; colorectal, n = 1; papillary thyroid, n = 1; appendiceal cancer, n = 1) with BRAF V600E mutation in the tumor tissue but not in cfDNA, one patient (papillary thyroid cancer) had wtBRAF when the tumor tissue (we used the same block as used for initial tissue testing, if possible) was tested with BEAMing. Here, BRAF is linked to thyroid gland papillary carcinoma.