Using reduced expression of Axin2 mRNA as a reporter, Liu et al screened many human tumor cells, including brain, lung, and colon cancers and lymphoma/leukemia, and only detected a few (31%, 31/96 cases) head and neck squamous cell carcinoma (HNSCC) cell lines that were sensitive to the PORCN inhibitor treatment. This evidence concerns the gene AXIN2 and head and neck squamous cell carcinoma.