IGF2R and melanoma: It has been well documented that miR-211 is a lineage-specific miRNA which is highly expressed in the melanocytic lineage and has been associated with melanoma cell invasiveness [12, 13, 31] via its direct regulation of POU3F2 (BRN2), IGF2R, TGFBR2, NFAT5, and NUAK1.