Studies in NB cell lines treated with miR-659-3p mimic and inhibitor indicated that miR-659-3p specifically modifies the expression of the transcription factor CNOT1, and the expression of the AU-rich element (ARE)-containing target genes AKT3, BCL2, CYR61 and THSB2, that belong to the focal adhesion pathway. The gene discussed is CNOT1; the disease is neuroblastoma.