In the miR-659-3p-transfected NB cell lines, the expression of AKT3, BCL2, CYR61 and THSB2 was confirmed to be specifically modified by miR-659-3p mimic and inhibitor, whereas that of RNASEL was not affected by the treatment and that of HEY1 and ZNF652 occurred in the wrong direction (Figure 3). This evidence concerns the gene CCN1 and neuroblastoma.