TGFBR2 and neoplasm: To further dissect the molecular mechanism(s) how miR-373-3p functions as a tumor suppressor to mediate the TR4-increased PCa cell invasion, we analyzed the miRNA prediction databases and found the linkage of miR-373-3p to TGFβR2 signals showing 4 potential positions to be targeted by miR-373-3p (Figure 5A).