TP53 and neoplasm: It was previously reported that the adenovirus mutant dl1520 (also named ONYX-015) with E1B55-kD deletion could preferentially target and lyse p53-dysfunctinal tumor cells but not in the adjacent normal cells [9], however, further studies denied this view point and proved that the adenovirus mutant can enhance the viral mRNA late nuclear transport and oncolysis for tumor selectivity [10].