Interestingly, several of these were mitochondrial constituents, including SLC25A12, CAV2, SDHB, DHRS2, ACADSB, PNPT1, PITRM1, TIMM50, SLC25A1, IARS2, and OAT, and we hypothesize that these mitochondrial proteins may contribute to the metabolic requirements needed for tumour formation. The gene discussed is ACADSB; the disease is neoplasm.