IARS2 and neoplasm: Interestingly, several of these were mitochondrial constituents, including SLC25A12, CAV2, SDHB, DHRS2, ACADSB, PNPT1, PITRM1, TIMM50, SLC25A1, IARS2, and OAT, and we hypothesize that these mitochondrial proteins may contribute to the metabolic requirements needed for tumour formation.