The knockdown of FAM84B expression in ESCC cell line CE81T/VGH showed delay in tumor growth with reduced tumor size of shFAM84B xenografts (96 mm3,p = 0.003) measured 33 days after subcutaneous injection of cells compared with shControl tumors (438 mm3, Fig. 5b). This evidence concerns the gene LRATD2 and esophageal squamous cell carcinoma.