Additionally, in agreement with recent work (Edwards et al., 2014), Treg-cell-expressed integrin αvβ8 appears dispensable for inhibition of the initial development of inflammation in models of colitis (when T cells and Treg cells are co-transferred into Rag2−/− mice), again suggesting that alternative pathways are important in keeping T cells in check at rest. Here, RAG2 is linked to colitis.