Finally, when natural chimera mice (female Itgb8fl/fl mice heterozygous for foxp3YFP-Cre) were subjected to either DSS colitis or DTH models, there were no differences in Itgb8-expressing (YFP−) and Itgb8-deficient (YFP+) Treg cell ratios compared to equivalent populations in chimeras where all Treg cells expressed integrin β8 (Figures S4I and S4J). Here, ITGB8 is linked to colitis.