Mice lacking Treg cell integrin β8 expression showed exacerbated colitis compared to control mice expressing Foxp3-YFP-Cre, showing enhanced weight loss (Figure 5A), increased CD4+ T cell numbers (Figure 5B), and enhanced pathology (Figure 5C), suggesting an important functional role for integrin αvβ8 expression on Treg cells in controlling intestinal inflammation. Here, CD4 is linked to colitis.