CHRNA7 and Sepsis: These alterations in the innate immune response, which include resistance to the inflammation-resolving cholinergic actions of α7nAChR agonists, fewer circulating regulatory T cells to orchestrate anti-inflammatory responses, and eicosanoid products that are pro-inflammatory in lieu of pro-resolving [26], are likely responsible for the exaggerated inflammation and concurrent impaired bacterial clearance in response to S. aureus bacteremic sepsis in rats.