In the current study, we carried out a comprehensive analysis of ROR1 protein expression in human lung adenocarcinoma tissues and cell lines and found that ROR1 protein is selectively expressed on lung adenocarcinoma, but almost absent from tumor-adjacent tissues and propose that ROR1 could mediate cell survival via the PI3K/AKT/mTOR signaling pathway. This evidence concerns the gene ROR1 and lung adenocarcinoma.