PMEL and lymphangioleiomyomatosis: This, coupled with the presence of cells which do not express melanoma markers, including the recently described αPEP13h, a high sensitivity antibody targeting PMEL/gp100 [27], in LAM nodules suggest these lesions contain multiple cell types and suggest that cells similar to activated fibroblasts are present in LAM nodules, and are likely to contribute to the lung pathology of LAM.