Previous studies in a murine xenograft model have shown efficacy of combination treatment of Len with LBH589, and that mice receiving combination treatment had longer survival than those treated with either Len or LBH589 alone.32 Importantly, our results suggest that potent class-I/II or class-I-selective HDACi reduce MM cell sensitivity to IMiDs due to downregulation of CRBN. The gene discussed is CRBN; the disease is Miyoshi myopathy.