More specifically, IMiDs bind to cereblon and promote proteasomal degradation of IKZF1 and IKZF3 to trigger MM cell growth inhibition.4, 5 Previous studies show that knockdown of CRBN confers resistance to IMiDs treatment.2, 3 In this study, we confirmed that CRBN knockdown H929 cells are less sensitive to IMiD treatment than parental cells. This evidence concerns the gene CRBN and Miyoshi myopathy.