IKZF1 and Miyoshi myopathy: Of note, knockdown of IKZF1/3 induces significant growth inhibition of MM cells.4, 5 Although human MM has multiple translocations involving IgH switch regions, c-MYC is infrequently involved as a partner in these translocations.6 However, it is commonly activated in MM, and knockdown of MYC induces MM cell death,7 suggesting that c-Myc represents a promising therapeutic target in MM.