CRBN and Miyoshi myopathy: ACY1215 in combination with proteasome inhibitors shows synergistic cytotoxicity in MM cells,16, 17 and combination treatment of ACY1215 with Len or BTZ is under clinical evaluation.33 Interestingly and in contrast to MS275 with Len combination, we did not observe downregulation of CRBN when ACY1215 was added to Len.