Ocular localization of the proteins that showed significantly higher expression in the vitreous than in blood (CCL2, IGFBP2, MMP10, HGF, TNFRSF11B) was investigated in histological specimens of eyes from patients with painful blindness due to secondary glaucoma after CRVO (Fig 2). The gene discussed is TNFRSF11B; the disease is Blindness.