Ad-CD80-TPE-GM, with the granulocyte-macrophage colony-stimulating factor (GM-CSF) gene and CD80 inserted into a TERTp driven CRAd had an oncolytic effect at an MOI of 0.1, and killed ~80% TERT-positive tumor cells within 7 days at an MOI of 1 [15]. Here, CD80 is linked to neoplasm.