DHTKD1 and neoplasm: Also, the replication capability of Ad-TERTp-E1A-1504 was similar to that of Ad-TERTp-E1A-NC, indicating that the enhanced antitumor efficacy of Ad-TERTp-E1A-1504 compared to Ad-TERTp-E1A-NC was not due to replication-inducing tumor cell lysis.