Western blot confirmed that Ad-TERTp-E1A-1504 and Ad-ΔE1-1504 significantly suppressed EphA3 and AKT, mTOR and 4-ebp1 phosphorylation compared with Ad-TERTp-E1A-NC and Ad-ΔE1-NC, respectively, in TERT- and EphA3-positive tumor cells. The gene discussed is TERT; the disease is neoplasm.