MAPT and Alzheimer disease: The characteristic pathological changes of AD mainly include differing degrees of neuronal loss or apoptosis, senile plaques (SP) formed by extracellular deposits of amyloid-β (Aβ), and intracellular neurofibrillary tangles (NFT) constituted by hyperphosphorylated microtubule-associated protein tau (Tau) in the brain[2].