However, as is demonstrated in Fig 3, the level of sema4A serum was significantly lower in both IBD groups (similarly low in both CD and UC patients) when compared to that of healthy individuals (5.69±1.48ng/ml for CD, 5.26±1.23 ng/ml for UC patients vs 9.74±2.73ng/ml for normal controls, P<0.001). Here, SEMA4A is linked to inflammatory bowel disease.