Interestingly, analysis revealed that the rs13405728 TT genotype in the LHCGR gene was related to the increased levels of T. As we known, hyperandrogenemia is considered one of the most important pathophysiological features in PCOS [29], and obesity aggravates menstrual irregularity and increase serum total testosterone level [30]. Here, LHCGR is linked to obesity due to melanocortin 4 receptor deficiency.