Furthermore, the macrophage inflammatory proteins (MIPs) MIP-1α and MIP-1β, which have been shown to increase bone resorption by osteoclasts in multiple myeloma [8], were also elevated in GD with bone disease [9, 10]; therefore, in combination with other cytokines, MIP-1α and MIP-1β might also contribute to pathological skeletal alterations in GD1. This evidence concerns the gene CCL3 and plasma cell myeloma.