On multivariate survival analysis, we found that the OS of HCC patients was significantly dependent on cirrhosis (p = 0.042), tumor nodule number (p = 0.014), vein invasion (p = 0.019) and TMEM100 expression levels (p = 0.021; Table 2), while DFS of HCC patients was significantly dependent on tumor nodule number (p = 0.028), vein invasion (p = 0.017) and TMEM100 expression levels (p = 0.026; Table 3). Here, TMEM100 is linked to Cirrhosis.