Furthermore, TMEM100 mRNA expression in the HCC cell line HepG2 and SMMC-7721 which with relative higher metastatic and proliferative potential [19], was very low (0.001 and 0.003), while in HCCLM3 and MHCC97-L which with relative lower metastatic and proliferative potential, TMEM100 mRNA expression was relatively high (0.47 and 0.03). Here, TMEM100 is linked to hepatocellular carcinoma.