Interestingly, one of the four clones (RC1) shows both overexpression of ROS1 and its ligand VAV3 (Figure 2B), a Rho GTPase guanine nucleotide exchange factor, associated with tumor growth, apoptosis, invasion and metastasis, and angiogenesis, which has also been shown to be phosphorylated and activated by ROS1 [21]. The gene discussed is VAV3; the disease is neoplasm.