Regarding the absence of proinflammatory HIF-1α and hypoxic NF-κB induction in MC-38 colon cancer cells, we were surprised to find that under the same conditions, RNA deep sequencing revealed that 77% of the hypoxically induced genes required p65/RelA and still 18% of the inflammatory genes required HIF-1α. The gene discussed is NFKB1; the disease is malignant colon neoplasm.