Meanwhile, inactivation of Tie-2 using siRNA (Figure 3C), a Tie-2-specific inhibitor or a Tie-2 Fc chimera (Figure 3D) also led to suppression of p27, even in the presence of recombinant Ang-1, further suggesting that Ang-1 induces quiescence of prostate cancer cells through the activation of Tie-2. Here, ANGPT1 is linked to Familial prostate cancer.