This is the case in seborrhea-acne-hirsutism-androgenetic alopecia (SAHA) syndrome, polycystic ovarian syndrome (PCOS), and hyperandrogenism, IR, and acanthosis nigricans (HAIR-AN) syndrome, conditions which may all require metabolic and hormonal evaluations as well as insulin-sensitizing medications [32]. This evidence concerns the gene INS and acne.