The treatment of SW837 colon cancer cell lines with 20 μg/mL of EGCG caused decrease in the phosphorylated form of the IGF-1R protein within 6 h and when SW837 cells were treated with EGCG for 96 h with concentration 1.0 μg/mL of EGCG, it also caused inhibition of activation of IGF-1R and decrease in the IGF-1 protein [79]. This evidence concerns the gene IGF1R and colonic neoplasm.