Experiment was performed to examine the effects of EGCG on vascular endothelial growth factor (VEGF) production by YCU-H891 HNSCC and MDA-MB-231 breast carcinoma cell lines and found that treatment with EGCG inhibited the constitutive activation of the EGFR, Stat3, and Akt in both cell lines [50]. The gene discussed is STAT3; the disease is head and neck squamous cell carcinoma.