The insulin-like growth factor I receptor (IGFIR) is constitutively activated in Ewing family tumors (EFTs) and (−)-epigallocatechin gallate (EGCG), a chief constituents green tea, inhibits cell proliferation and survival of EFT cells through the inhibition of IGFIR activity and also EGCG treated EFT cell lines blocked the autophosphorylation of IGFIR tyrosine residues [78]. Here, IGF1R is linked to Ewing sarcoma/peripheral primitive neuroectodermal tumor.