LRRK2 and Parkinson disease: In another of our previous studies, we have shown that LRRK2 can interact with and phosphorylate Akt and that PD-associated LRRK2 mutants (R1441C, G2019S, and I2020T) show a reduced degree of interaction with and phosphorylation activity toward Akt in comparison with WT-LRRK2 [76].