MAP3K4 and type 2 diabetes mellitus: Among them is HSPA2, a chaperone that inhibits aggregation and mediates folding of newly translated polypeptides [62], and SEPP1, that plays central role in selenium homeostasis [63, 64] and has been linked to glucose metabolism and type 2 diabetes [65], as well as several members of the ROS-activated MAPK family (e.g., MAPK1, MAP2K1, MAP3K4, and MAP4K3) [66, 67].