BNP levels rise primarily in the presence of left ventricular dysfunction: the most recent clinical guidelines on heart failure (HF) management suggest its measurement to support clinical decision regarding the diagnosis and to establish prognosis or disease severity in ambulatory patients with dyspnea [16], in chronic HF [17], in hospitalized subjects [18, 19], and in acute decompensated HF (ADHF) [20] (Class I, Level of Evidence A). Here, NPPB is linked to heart failure.