Son et al. found that endogenous IL-8 mRNA expression was reduced by doxycycline treatment in a dose-dependent manner in pancreatic cancer cells (PANC-1) and that TNF-α-induced IL-8 mRNA expression was effectively blocked by 48 h of doxycycline pretreatment [33]. This evidence concerns the gene CXCL8 and familial pancreatic carcinoma.