PET imaging with 64Cu-labeled DOTATATE is not equivalent to PET imaging with 18F-FDG as previously shown.7 The exact role of different macrophage subsets including CD163+ macrophages of the hemorrhage-associated phenotype in atherosclerosis needs further elucidation, and future studies will have to show whether 64Cu-DOTATATE has higher specificity than 18F-FDG for imaging vulnerability of plaques. This evidence concerns the gene CD163 and atherosclerosis.