Certain viral infections have already been reported to lead to increased BiP expression, including members of the Flaviviridae family, such as dengue virus (DENV) [16, 17], West Nile virus (WNV) [18], and HCV [19], in addition to CMV [20] and enterovirus 71 (EV71) [21]. Here, HSPA5 is linked to viral infectious disease.