Similarly, Nrf2-KO mice are more sensitive to, whereas genetic or pharmacological activation of Nrf2 has protective effects against, neurotoxicity caused by the complex I inhibitor 1-methyl-4-phenylpyridinium ion in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine animal model of Parkinson׳s disease [49], [50], [51], [52], [53], [54], [55], [56], [57], [58], [59], [60], [61]. Here, NFE2L2 is linked to Parkinson disease.