In addition, exogenous gene transfection of Nkx2.5 or GATA-4 into myocardial cell extracellular environment co-cultured BMSCs was able to enhance the ability to repair, mitigate the death of the myocardial cells and activate myocardium in myocardial infarction-induced rabbits. Here, GATA4 is linked to myocardial infarction.