In addition, several genes involved in this process have been identified: Cystathionine-γ-lyase serves an important pro-inflammatory role via nuclear factor κB activation in caerulein-induced pancreatitis (4); S-propargyl-cysteine protects caerulein-induced acute pancreatitis via its involvement in the slow release of endogenous hydrogen sulfide (5); and neutral endopeptidase (NEP) is anti-inflammatory in caerulein-induced acute pancreatitis, with acute inhibition of NEP contributing to increased substance P levels (6). This evidence concerns the gene MME and pancreatitis.