TF and rheumatoid arthritis: Interestingly, therefore, given the convergence of hypoxia, reactive oxygen species (ROS) and the inflammasome in promoting the inflammation and angiogenesis that leads to joint damage in RA [21–25], a large group of genes, involved in protection against oxidative stress and controlled by this TF were up-regulated by SMA-12b (Supplementary Tables 1 and 2).