Moreover, as osteoclasts, the cells responsible for bone resorption in chronically inflamed joints, can arise from the same progenitors as macrophages, it is intriguing in the context of RA that microarray analysis suggests that 12b can downregulate the transcription factor NFAT-C1, which has been proposed to be a master regulator of the osteoclast transcriptome [60] and can be induced in a TLR2/MyD88-dependent manner [61]. This evidence concerns the gene NFATC1 and rheumatoid arthritis.