Therefore, the present study aimed to investigate the expression and clinical significance of HIF-1α, Snail and E-cadherin in the human mucinous ovarian cancer cell line 3AO, the serous ovarian cancer cell line SKOV3, the human clear cell ovarian cancer cell line ES-2 and the undifferentiated human ovarian cancer cell line TYK, as well as in ovarian cancer tissues. This evidence concerns the gene HIF1A and ovarian cancer.