To determine whether RBP2 was critical for EMT and stemness maintenance through repressing E-cadherin, we treated GC cell lines with both RBP2 siRNA and E-cadherin siRNA and found that the capacity of cell migration and stemness maintenance inhibition by RBP2 knockdown were relieved by E-cadherin suppression simultaneously (Figure 4h and 4i), which potently implicated RBP2 played a pivotal role in EMT process by means of inhibiting E-cadherin expression. Here, RBP2 is linked to gastric cancer.