Among the cohort of 19 tumors, active caspase-3 staining displayed a mean score of 24, 4% (ranging from 0 to 70%) in YM155-treated tumors compared to 4, 5% (ranging from 0 to 10%) in untreated (vehicle-treated) tumors (Figure 1B), indicating that YM155 significantly induced apoptosis in primary breast tumor cells. This evidence concerns the gene CASP3 and breast neoplasm.