In addition, in breast cancer cell lines upon YM155 treatment, we observe not only caspase-3 activation, as previously reported [22], but also Bax cleavage, suggesting that activation of a cascade of proteases including calpains involved in Bax proteolysis [23, 24] and caspases, happened in response to YM155. The gene discussed is CASP3; the disease is breast carcinoma.