The role of the Tau amino-terminal domain with regard to microtubules hasbeen reported as being indirect, such as by the regulation of microtubulespacing40 and functions41, 42.Nevertheless, in lines with our data, in vitro studies of the impact ofmissense mutations encountered in Tauopathies (mutations at the Arg5 and at Gly55residues) suggest that the modification of the amino-terminal domain of Tau coulddirectly impact microtubules43, 44, 45. Here, MAPT is linked to tauopathy.