The translational importance of this not only relates to enhancing our understanding of the pathogenesis of NAFLD, but also to the widespread use of SRD5A2 inhibitors including the selective, SRD5A2 inhibitor, finasteride, and the nonselective (SRD5A1 and 2) inhibitor, dutasteride. Here, SRD5A2 is linked to metabolic dysfunction-associated steatotic liver disease.